Tetrahydrocannabinol (THC)

Tetrahydrocannabinol Isomers, Delta-8, Delta-9 and overview of THC-V (Varient)

The Delta-8 Controversy


THC presents itself as two different isomers, delta-9-tetrahydrocannabinol and delta-8-tetrahydrocannabinol. Delta-8 is essentially an analogue of Delta-9. It works in the same way in that it is a partial agonist of the CB1 and CB2 receptors and has a particularly high binding affinity with the CB1 receptor.


There are claims that Delta-8 is less psychoactive than Delta-9 but this has not yet been backed up with scientific evidence.


The only difference between Delta-8 and Delta-9 is where the double bond is located on the chain of atoms. With Delta 8 the double bond is on the eighth carbon atom in the molecular structure, with Delta 9 the double bond is located on the ninth.


THC-V (Varient)


Another homologue of THC is THC-V. Although a variant of THC having a propyl (3-carbon) side chain instead of a pentyl (5-carbon) group on the molecule, it produces very different effects.


THC-V increases satiety and up-regulates energy metabolism, making it a clinically useful remedy for weight loss and management of obesity and type 2 diabetic patients.


The distinctions between THC-V and THC in terms of glycemic control, glucose metabolism, and energy regulation have been demonstrated in previous studies.


The effect of THC-V on dyslipidemia and glycemic control in type 2 diabetics has shown reduced fasting plasma glucose concentration when compared to a placebo group.


THC-V has the ability to provide neuroprotection, appetite suppression, glycemic control, and mitigation of side effects, therefore, making it a potential priority candidate for the development of clinically useful therapies in the future.


| C21H30O|

Image: THC Molecular Structure - Double bond location differs in Delta-8 and Delta-9